Newsletter | January 8, 2025

01.08.25 -- 2025 Outlook From RNA Leaders

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Though the number of CDMOs with mRNA/RNA capabilities is increasing, many of these are better equipped for large-scale, linear mRNA development. Don't miss Advancing RNA Live on January 21st as our panel shares how mRNA and next-gen RNA modality companies need to be evaluating CDMO platforms. Attendance is free thanks to the support of Cytiva.

FEATURED EDITORIAL

"The Ghost Of mRNA's Future": 2025 Outlook From RNA Leaders

As the Charles Dickens fans among us already know, there is still one pretty important “ghost” that has yet to be channeled on this “hallowed” page, and that’s the “Ghost of mRNA/RNA Innovations Yet To Come.” (Yes. That’s a thing.) Here, I share several future-facing “visions” from the conversations I had with five RNA leaders.

CMC Strategies With CDMOs: Ensuring CQAs For Oligos And Peptides

Developing a practical chemistry, manufacturing, and controls (CMC) strategy for oligonucleotides and peptides demands a shift in approach in terms of the way you collaborate with your CDMO.

Goldilocks & The 3…CQAs? Finding "Just Right" With LNP Optimization

Three LNP experts from Sanofi, Hopewell Therapeutics, and BioNTech collectively discuss how far we’ve come in understanding the structure of our LNPs while also shedding light on the variables that have the greatest potential of causing shifts in our products’ structure/function.

Sourcing Plasmid DNA From CDMOs Got More Challenging — Here's Why

The demand for plasmid DNA products is intrinsically linked to unique market conditions and funding environments. Here's what's driving them.

INDUSTRY INSIGHTS

Demystifying CRISPR gRNA Chemical Modifications

Chemical modifications on CRISPR gRNAs enhance stability, editing efficiency, and reduce immune responses, enabling in vivo applications and clinical success.

mRNA Process And Cost Modeling: A Tool To Optimize Process Development

Demand for mRNA-based medicine production continues to increase, as do investments in prophylactic and therapeutic indications. Explore a cost-model that compares all modalities.

Empowering A New Era Of Patient-Centric Medicines

Discover the challenges pharma companies are facing as they switch focus as well as the actions and technologies companies are implementing to help achieve a brighter future for patients.

Establishing Analytical Methods For Emerging mRNA-Based Therapies

Here, we describe the use of cutting-edge technologies to assess critical quality attributes of both mRNA drug substances and drug products.

How To Plan For Trouble-Free Filter Validation

Watch to learn when filter validation should be performed, what is required from an end user and laboratory testing perspective, and how to achieve first-time success for various drug products.

How Repair Biotech Enhances mRNA Efficacy And Trial Feasibility

Learn how enhanced efficacy, reduced costs, and streamlined clinical trials helped to pave the way for the next generation of breakthrough treatments for cholesterol and aging-related diseases.